*Diabetes insipidus facts Medically Edited by: Melissa Conrad Stöppler, MD

  • Diabetes insipidus is not related to diabetes mellitus (type 1 andtype 2 diabetes).
  • Diabetes insipidus is caused by problems related to the antidiuretic hormone (ADH) or its receptor and causes frequent urination.
  • There are four types of diabetes insipidus; 1) central diabetes insipidus, 2) nephrogenic diabetes insipidus, 3) dipsogenic diabetes insipidus, and 4) gestational diabetes insipidus.
  • The most common symptom of diabetes insipidus is frequent urination.
  • The diagnosis for diabetes insipidus is based on a series of tests (for example, urinalysis and fluid deprivation test).
  • The treatment for diabetesinsipidus depends on the type of diabetes insipidus.
  • Diabetes can lead to chronickidney disease.
  • Diabetes is the most common cause of kidney failure in the US.

What is diabetes insipidus, and what are the symptoms of the condition?

Diabetes insipidus (DI) is a rare disease that causes frequent urination. The large volume of urine is diluted, mostly water. To make up for lost water, a person with diabetes insipidus may feel the need to drink large amounts and is likely to urinate frequently, even at night, which can disruptsleep and, on occasion, cause bedwetting. Because of the excretion of abnormally large volumes of dilute urine, people with diabetes insipidus may quickly become dehydrated if they do not drink enough water. Children with diabetes insipidus may be irritable or listless and may have fever,vomiting, or diarrhea. Milder forms of diabetes insipidus can be managed by drinking enough water, usually between 2 and 2.5 liters a day. Diabetes insipidus severe enough to endanger a person’s health is rare. 

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